LACDR research in PNAS


Just before the holidays, researchers of the division of Medical Pharmacology published a paper in PNAS in which they reveal an important factor in the brain’s response to stress (PNAS 2009,  106(19):8038-42).

Lachize et al demonstrate that two genes that are crucial for the way we cope with stress (coding for the peptides CRH and POMC), depend on the protein steroid receptor coactivator-1 (SRC-1) for their response to glucocorticoid stress hormones. In addition, the coactivator seems to function as an integrator of different stress signals, a.o. in brain areas responsible for the regulation of fear and anxiety.

The work, funded by a ZON-MW Vidi project of Onno Meijer, has interesting consequences for the use of glucocorticoid receptor ligands. SRC-1 is one out of several proteins that can function as effector pathways of glucocorticoid signaling. Which of these effector pathways is recruited is in part determined by the specific ligand that binds the glucocorticoid receptors. The dependence of stress-related factors on SRC-1 suggests that is will be possible to selectively target the stress system with novel glucocorticoid receptor ligands.

For more info on the publication, please check the PNAS website