Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes: Protective Effects of Glucocorticoid Receptor Antagonists

Publication Type:

Book Chapter

Source:

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis, Wiley-VCH Verlag GmbH & Co. KGaA, p.103-120 (2011)

ISBN:

9783527633968

DOI Name (links to online publication)

10.1002/9783527633968.ch6

Keywords:

adult neurogenesis; stress; glucocorticoid; depression; diabetes; mifepristone; hippocampus

Abstract:

This chapter contains sections titled: * The Stress Response * HPA Axis and Glucocorticoids * Glucocorticoid Actions * Feedback Regulation * Stress and Depression * Stress-Induced Viability Changes in the Hippocampus: Effect on Function, Volume, Cell Number, and Apoptosis * Effects of Stress on Dendritic Atrophy, Spine, and Synaptic Changes * Adult Hippocampal Neurogenesis * Effect of Stress on Adult Hippocampal Neurogenesis * Normalization of the Effects of Stress on the Hippocampus by Means of GR Blockade * Normalization of Hippocampal Alterations during Diabetes Mellitus Using the GR Antagonist Mifepristone * Concluding Remarks * Acknowledgments * Disclosure * References

18/01/2013