Corticosteroid Hormones in Stress and Anxiety – Role of Receptor Variants and Environmental Inputs

Publication Type:

Book Chapter

Source:

Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses, Wiley-VCH Verlag GmbH & Co. KGaA, p.117-150 (2009)

ISBN:

9783527628346

DOI Name (links to online publication)

10.1002/9783527628346.ch7

Keywords:

stress; brain; depression; anxiety; corticosteroids; glucocorticoid receptors; mineralocorticoid receptors; single nucleotide polymorphisms

Abstract:

This chapter contains sections titled: * Introduction * Corticosteroid Hormones, Fear and the Stress Response * Gene Variants and Early Life Experiences * MR and GR Gene Structure * Genetic Variants of the MR and GR Genes * HPA Axis Regulation * Epigenetic Modifications Affecting GR and MR Actions * Stress-Related Psychopathology * Early Experience and Psychopathology * Genetic Variants and Psychopathology * Concluding Remarks * Summary * References

18/01/2013