Antiglucocorticoids, neurogenesis and depression

Publication Type:

Journal Article

Source:

Mini Rev Med Chem, Volume 9, Number 2, p.249-264 (2009)

ISBN:

1389-5575 (Print)1389-55

Keywords:

Animals; Antidepressive Agents/*pharmacology; Depression/*drug therapy/*metabolism; Glucocorticoids/*antagonists; &; inhibitors; Humans; Hypothalamo-Hypophyseal System/physiology; Models; Molecular; Nerve Tissue/*growth; &; development; Receptors; Glu

Abstract:

Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.

18/01/2013