Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice

Publication Type:

Journal Article

Source:

Prog Brain Res, Volume 167, p.257-261 (2008)

ISBN:

0079-6123 (Print)0079-61

DOI Name (links to online publication)

10.1016/S0079-6123(07)67019-8

Keywords:

Animals; Behavior; Animal/*physiology; Conditioning; Classical; Corticosterone/blood; Fear/physiology/*psychology; Glucocorticoids/*metabolism; Individuality; Male; Memory/physiology; Mice; Mice; Inbred BALB C; Mice; Inbred C57BL; Species Specificity

Abstract:

"Pavlovian" fear conditioning in rodents allows studying the formation and extinction of fear memories. Male C57BL/6J but not BALB/c mice showed differential fear memory performance expressed as freezing and scanning behaviour for context and cue. Glucocorticoid stress hormones modulate the processing of fear-related stimuli. The augmented corticosterone response of BALB/c mice to conditioning and testing, therefore, might have contributed to the strain-dependent formation of fear memories. We propose that modulation of extinction processes by glucocorticoids can be relevant in modelling anxiety disorders.

18/01/2013