Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice

Publication Type:

Book Chapter

Source:

Stress Hormones and Post Traumatic Stress Disorder: Basic Studies and Clinical Perspectives, Elsevier Science Bv, Volume 167, Amsterdam, p.257-261 (2007)

ISBN:

0079-6123978-0-444-53140

DOI Name (links to online publication)

10.1016/s0079-6123(07)67019-8

Keywords:

PTSD; fear conditioning; C57BL/6J and BALB/c mice; stress system; hippocampal volume; memory; exposure

Abstract:

"Pavlovian" fear conditioning in rodents allows studying the formation and extinction of fear memories. Male C57BL/6J but not BALB/c mice showed differential fear memory performance expressed as freezing and scanning behaviour for context and cue. Glucocorticoid stress hormones modulate the processing of fear-related stimuli. The augmented corticosterone response of BALB/c mice to conditioning and testing, therefore, might have contributed to the strain-dependent formation of fear memories. We propose that modulation of extinction processes by glucocorticoids can be relevant in modelling anxiety disorders.

18/01/2013