No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus

Publication Type:

Journal Article

Source:

Brain Res, Volume 1093, Number 1, p.161-166 (2006)

ISBN:

0006-8993 (Print)0006-89

DOI Name (links to online publication)

10.1016/j.brainres.2006.03.083

Keywords:

Animals; Anti-Inflammatory Agents/*pharmacology; Corticosterone/*pharmacology; Hippocampus/*drug effects/metabolism; Immediate-Early Proteins/biosynthesis/*drug effects; In Situ Hybridization; Male; Neural Cell Adhesion Molecules/biosynthesis/*drug effect

Abstract:

Prolonged over-exposure of rats to corticosterone attenuates 5-HT(1A)-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT(1A) receptor expression. We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.

18/01/2013