Corticosteroid resistance in a subpopulation of multiple sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production

Publication Type:

Journal Article

Source:

J Neuroimmunol, Volume 151, Number 1-2, p.180-188 (2004)

DOI Name (links to online publication)

10.1016/j.jneuroim.2004.02.009

Keywords:

Adrenal Cortex; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Behavior; biosynthesis; blood; Blood Cells; Cells; Cultured; Comparative Study; Dexamethasone; drug effects; Drug Resistance; Female; Health; Hormones; Humans; immunology; In Vitro;

Abstract:

We assessed corticosteroid sensitivity in multiple sclerosis (MS) patients compared to control subjects, using an in vitro assay of dexamethasone (Dex) inhibition of lipopolysaccharide (LPS) stimulated-blood interleukin-6 production. Significantly higher concentrations of dexamethasone were needed to obtain 50%-inhibition (ID(50)) of in vitro LPS stimulated interleukin (IL)-6 production (28.4 x 10(-7) M) in relapsing-remitting MS (RRMS) patients compared to chronic progressive MS (CPMS) patients (6.2 x 10(-7) M) or compared to controls (3.0 x 10(-7) M). We also found a trend towards worsening of clinical status over time with increasing corticosteroid resistance. These data suggest that corticosteroid sensitivity may be a factor in the pathogenesis and could be used for prognosis of MS

18/01/2013