Stress Hyporesponsive Period

Publication Type:

Book Chapter


Encyclopedia of Stress, Academic Press, Volume 1st, New York, p.518-526 (2000)


AXIS; Behavior; corticosteroid; corticosteroids; Development; ENDOCRINE; glucocorticoid; GLUCOCORTICOID-RECEPTOR; GLUCOCORTICOID-RECEPTORS; GLUCOCORTICOID RECEPTOR; glucocorticoid receptors; GR; HPA; Maternal Behavior; RECEPTOR; RECEPTORS; RESPONSES; Stre


The stress hyporesponsive period initially described a period during development when the endocrine responses to stress were markedly diminished. Subsequent studies indicated that the rodent pup can respond selectively to systemic stimuli. Downregulation of the neonate's hypothalamic-pituitary-adrenocortical (HPA) axis is in part regulated by maternal behaviors and by corticosteroids acting on the glucocorticoid receptors (GRs)