Regional distribution of a novel calcium/calmodulin-dependent protein kinase mRNA in the rat brain

Publication Type:

Journal Article


Brain Res, Volume 835, Number 2, p.365-8 (1999)


0006-8993 (Print)0006-89

DOI Name (links to online publication)



Animals; Brain/*metabolism; Calcium-Calmodulin-Dependent Protein Kinases/*genetics; Gene Expression Regulation; Enzymologic/*physiology; In Situ Hybridization; Limbic System/metabolism; Male; RNA; Messenger/*analysis; Rats; Rats; Wistar


The regional distribution of a novel Ca(2+)/calmodulin-dependent protein kinase (CaMK-VI) was examined in the adult rat brain by in situ hybridization. High levels of CaMK-VI mRNA were detected in the hippocampus, piriform cortex and habenula, moderate levels in different thalamic nuclei and cerebral cortex, and low levels in the frontal and parietal cortex. This discrete distribution pattern suggests an important role for CaMK-VI in limbic brain regions.