Anti-aggressive effect of a new phenylpiperazine compound (DU27716) on hypothalamically induced behavioural activities

Publication Type:

Journal Article

Source:

Pharmacol Biochem Behav, Volume 17, Number 1, p.147-153 (1982)

DOI Name (links to online publication)

10.1016/0091-3057(82)90277-5

Keywords:

Aggression; Animals; ATTACK; Behavior; Animal; behaviour; drug effects; DRUGS; Electric Stimulation; electrical stimulation; ELECTRICAL-STIMULATION; Electrodes; Human; Hypothalamic; Hypothalamus; Locomotion; Male; MALE-RATS; MODEL; Motor Activity; pharmaco

Abstract:

Using the same hypothalamic electrodes, the following behaviour was evoked in male rats by electrical stimulation at roughly equal current intensities: attacks on a partner, teeth-chattering, switch-off behaviour and locomotion. Current thresholds were determined for each behaviour following the intraperitoneal administration of saline or DU27716, a new phenylpiperazine compound with interesting inhibitory effects on territorial and intermale aggression. DU27716 raised current thresholds for attack and teeth-chattering beginning at the lowest dose (4 mg/kg), whereas there was no effect on switch-off behaviour, and only a slight but significant effect on locomotion thresholds at the highest dose (8 mg/kg). The results provide support for the hypothesis that DU27716 possesses behaviourally selective, anti-aggressive properties, and illustrate the usefulness of hypothalamically induced behaviours as a pharmacological model

18/01/2013