Recent publications

2013
Diamantopoulou, A., Raftogianni, A., Stamatakis, A., Oitzl, M.S., Stylianopoulou, F. , Effects of denial of reward through maternal contact in the neonatal period on adult hypothalamic-pituitary-adrenal axis function in the rat, Psychoneuroendocrinology, vol. 38, issue 6, pp. 830-841. DOI
Albrecht, A., Caliskan, G., Oitzl, M.S., Heinemann, U., Stork, O. , Long-Lasting Increase of Corticosterone After Fear Memory Reactivation: Anxiolytic Effects and Network Activity Modulation in the Ventral Hippocampus, Neuropsychopharmacology, vol. 38, pp. 386–394. DOI
Harris, A.P., Holmes, M.C., de Kloet, E.R., Chapman, K.E., Seckl, J.R. , Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour, Psychoneuroendocrinology, vol. 38, no. 5, pp. 648-658. DOI
Schumann, G., Binder, E.B., Holte, A., de Kloet, E.R., Oedegaard, K.J., Robbins, T.W., Walker-Tilley, T.R., Bitter, I, Brown, V.J., Buitelaar, J., Ciccocioppo, R., Cools, R., Escera, C., Fleischhacker, W., Flor, H., Frith, C.D., Heinz, A., Johnsen, E., Kirschbaum, C., Klingberg, T., Lesch, K.P., Lewis, S., Maier, W., Mann, K., Martinot, J.L., Meyer-Lindenberg, A., Muller, C.P., Muller, W.E., Nutt, D.J., Persico, A., Perugi, G., Pessiglione, M., Preuss, U.W., Roiser, J.P., Rossini, P.M., Ryba, , Stratified medicine for mental disorders, Eur Neuropsychopharmacol. DOI
Zalachoras, I, Houtman, R., Atucha, E., Devos, R., Tijssen, A.M., Hu, P., Lockey, P.M., Datson, N.A., Belanoff, J.K., Lucassen, P.J., Joels, M., de Kloet, E.R., Roozendaal, B., Hunt, H., Meijer, O.C. , Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator, PNAS, vol. 110, no. 19, pp. 7910-7015. DOI
Evers, M.M., Tran, H.D., Zalachoras, I, Pepers, B.A., Meijer, O.C., den Dunnen, J.T., van Ommen, G.J., Aartsma-Rus, A., van Roon-Mom, W.M. , Ataxin-3 protein modification as a treatment strategy for Spinocerebellar Ataxia type 3: Removal of the CAG containing exon, Neurobiology of disease. DOI
Aubert, Y., Bohl, M.A., Lange, J.R., Diol, N.R., Allers, K.A., Sommer, B., Datson, N.A., Abbott, D.H. , Chronic systemic administration of serotonergic ligands flibanserin and 8-OH-DPAT enhance HPA axis responses to restraint in female marmosets, Psychoneuroendocrinology, vol. 38, no. 1, pp. 145-154. DOI
Zalachoras, I, Houtman, R., Meijer, O.C. , Understanding stress-effects in the brain via transcriptional signal transduction pathways, Neuroscience, vol. 242, pp. 97-109. DOI
Daskalakis, N.P., Bagot, R.C., Parker, K.J., Vinkers, C.H., de Kloet, E.R. , The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome, Psychoneuroendocrinology. DOI
Zalachoras, I, Grootaers, G., van Weert, L.T., Aubert, Y., de Kreij, S.R., Datson, N.A., van Roon-Mom, W.M., Aartsma-Rus, A., Meijer, O.C. , Antisense-mediated isoform switching of steroid receptor coactivator-1 in the central nucleus of the amygdala of the mouse brain, BMC neuroscience, vol. 14, no. 1, pp. 5. DOI
Vreeburg, S.A., Hoogendijk, W.J., de Rijk, R.H., van Dyck, R., Smit, J.H., Zitman, F.G., Penninx, B.W. , Salivary cortisol levels and the 2-year course of depressive and anxiety disorders, Psychoneuroendocrinology. DOI
Eising, E., Datson, N.A., van den Maagdenberg, A.M., Ferrari, M.D. , Epigenetic mechanisms in migraine: a promising avenue?, BMC medicine, vol. 11, no. 1, pp. 26. DOI
Ter Horst, J.P., Kentrop, J., de Kloet, E.R., Oitzl, M.S. , Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice, Behavioural Brain Research, vol. 241, pp. 92-95. DOI
Fitzsimons, C.P., van Hooijdonk, L.W., Schouten, M., Zalachoras, I, Brinks, V., Zheng, T., Schouten, T.G., Saaltink, D.J., Dijkmans, T., Steindler, D.A., Verhaagen, J., Verbeek, F.J., Lucassen, P.J., de Kloet, E.R., Meijer, O.C., Karst, H., Joels, M., Oitzl, M.S., Vreugdenhil, E. , Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior, Molecular Psychiatry, vol. 18, issue 9, pp. 993-1005. DOI
Schilling, T.M., de Ferreira Sa, D.S., Westerhausen, R., Strelzyk, F., Larra, M.F., Hallschmid, M., Savaskan, E., Oitzl, M.S., Busch, H.P., Naumann, E., Schachinger, H. , Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation, Human brain mapping. DOI
Reynolds, R.M., Hii, H.L., Pennell, C.E., McKeague, I.W., de Kloet, E.R., Lye, S., Stanley, F.J., Mattes, E., Foster, J.K. , Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis, Psychoneuroendocrinology, vol. 38, no. 8, pp. 1271-1280. DOI
Kruk, M.R., Haller, J., Meelis, W., de Kloet, E.R. , Mineralocorticoid receptor blockade during a rat's first violent encounter inhibits its subsequent propensity for violence, Behavioral Neuroscience, vol. 127, no. 4, pp. 505-514. DOI
Datson, N.A., van den Oever, J.M., Korobko, O.B., Magarinos, A.M., de Kloet, E.R., McEwen, B. , Prior history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus, Endocrinology. DOI
Speksnijder, N. , Determinants of psychosis vulnerability: Focus on MEF2- and glucocorticoid signaling, LACDR, Medical Pharmacology, vol. PhD, Leiden, Leiden University, pp. 160.
de Kloet, E.R., Joels, M. , Stress Research: Past, Present, and Future, Neuroscience in the 21st Century: Springer New York, pp. 1979-2007. DOI
de Kloet, E.R. , Resilience and Vulnerability: A Matter of Stress, Genes and Balance, Biological Psychiatry, vol. 73, no. 9, pp. 112s-112s. DOI
Ter Horst, J.P., Kentrop, J., Arp, M., Hubens, C.J., de Kloet, E.R., Oitzl, M.S. , Spatial learning of female mice: a role of the mineralocorticoid receptor during stress and the estrous cycle, Frontiers in Behavioral Neuroscience, vol. 7, pp. 56. DOI
Verissimo, C.S., Elands, R., Cheng, S., Saaltink, D.J., ter Horst, J.P., Alme, M.N., Pont, C., van de Water, B., Håvik, B., Fitzsimons, C.P., Vreugdenhil, E. , Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth, PLoS One, vol. 8, no. 9: Public Library of Science, pp. e75752. DOI
2012
Joels, M., de Kloet, E.R. , Nothing is written in stone, Biological Psychiatry, vol. 72, no. 6, pp. 432-433. DOI
Verissimo, C.S., Molenaar, J.J., Meerman, J.H., Puigvert, J.C., Pont, C., Danen, E.H.J., van de Water, B., Versteeg, R., Fitzsimons, C.P., Vreugdenhil, E. , Doublecortin-Like Kinase: A Potential Therapeutic Target for Neuroblastoma, Neuro-Oncology, vol. 14, no. Suppl. 3, pp. 91-91. DOI
Polman, J.A., Hunter, R.G., Speksnijder, N., van den Oever, J.M., Korobko, O.B., McEwen, B.S., de Kloet, E.R., Datson, N.A. , Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History, Endocrinology, vol. 153, no. 9, pp. 4317-4327. DOI
Claessens, S.E., Belanoff, J.K., Kanatsou, S., Lucassen, P.J., Champagne, D.L., de Ronald Kloet, E. , Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy, Brain Research, vol. 1482, pp. 1-12. DOI
Polman, J.A., Welten, J.E., Bosch, D.S., de Jonge, R.T., Balog, J., van der Maarel, S.M., de Kloet, E.R., Datson, N.A. , A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells, BMC neurosci, vol. 13, no. 1, pp. 118. DOI
Hunter, R.G., Murakami, G., Dewell, S., Seligsohn, M., Baker, M.E., Datson, N.A., McEwen, B.S., Pfaff, D.W. , Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response, Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 43, pp. 17657-17662. DOI
de Vrij, J., Dautzenberg, I.J., van den Hengel, S.K., Magnusson, M.K., Uil, T.G., Cramer, S.J., Vellinga, J., Verissimo, C.S., Lindholm, L., Koppers-Lalic, D., Hoeben, R.C. , A cathepsin-cleavage site between the adenovirus capsid protein IX and a tumor-targeting ligand improves targeted transduction, Gene Ther, vol. 19, no. 9, pp. 899-906. DOI
Ter Horst, J.P., de Kloet, E.R., Schachinger, H., Oitzl, M.S. , Relevance of Stress and Female Sex Hormones for Emotion and Cognition, Cell Mol Neurobiol, vol. 32, no. 5, pp. 725-735. DOI
Witzmann, S.R., Turner, J.D., Meriaux, S.B., Meijer, O.C., Muller, C.P. , Epigenetic regulation of the glucocorticoid receptor promoter 1 7 in adult rats, Epigenetics, vol. 7, no. 11, pp. 1290-1301. DOI
Speksnijder, N., Christensen, K.V., Didriksen, M., De Kloet, E.R., Datson, N.A. , Glucocorticoid Receptor and Myocyte Enhancer Factor 2 Cooperate to Regulate the Expression of c-JUN in a Neuronal Context, J Mol Neurosci, vol. 48, no. 1, pp. 209-218. DOI
Saaltink, D.J., Håvik, B., Verissimo, C.S., Lucassen, P., Vreugdenhil, E. , Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: Implications for neurogenesis, J Comp Neurol, vol. 13, pp. 2805–2823. DOI
Tolmacheva, E.A., Oitzl, M.S., van Luijtelaar, G. , Stress, glucocorticoids and absences in a genetic epilepsy model, Horm Behav, vol. 61, no. 5, pp. 706-710. DOI
Groeneweg, F.L., Karst, H., de Kloet, E.R., Joels, M. , Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling, Mol Cell Endocrinol, vol. 350, no. 2, pp. 299-309. DOI
Oitzl, M.S., Schwabe, L., Aggleton, J.P. , Memory formation: Its changing face, Neurosci Biobehav Rev, vol. 36, no. 7, pp. 1577–1578. DOI
Schnörr, S.J., Steenbergen, P.J., Richardson, M.K., Champagne, D.L. , Measuring thigmotaxis in larval zebrafish, Behav Brain Res, vol. 228, no. 2, pp. 367-374. DOI
Converse, A.K., Aubert, Y., Farhoud, M., Weichert, J.P., Rowland, I.J., Ingrisano, N.M., Allers, K.A., Sommer, B., Abbott, D.H. , Positron emission tomography assessment of 8-OH-DPAT-mediated changes in an index of cerebral glucose metabolism in female marmosets, Neuroimage, vol. 60, no. 1, pp. 447-55. DOI
Ter Horst, J.P., Carobrez, A.P., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Sex differences in fear memory and extinction of mice with forebrain-specific disruption of the mineralocorticoid receptor, Eur J Neurosci, vol. 36, no. 8, pp. 3096–3102. DOI
Daskalakis, N.P., Oitzl, M.S., Schachinger, H., Champagne, D.L., de Kloet, E.R. , Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity, Physiol Behav, vol. 106, no. 5, pp. 707–721. DOI
Strelzyk, F., Hermes, M., Naumann, E., Oitzl, M.S., Walter, C., Busch, H.P., Richter, S., Schachinger, H. , Tune it down to live it up? Rapid, nongenomic effects of cortisol on the human brain, J Neurosci, vol. 32, no. 2, pp. 616-625. DOI
Claessens, S.E., Daskalakis, N.P., Oitzl, M.S., de Kloet, E.R. , Neonatal Handling Rescues Later-Life Cognitive Impairment Programmed by Early-Life Glucocorticoid Treatment, Age and Ageing, vol. 41, pp. 47-47. DOI
Aubert, Y., Gustison, M.L., Gardner, L.A., Bohl, M.A., Lange, J.R., Allers, K.A., Sommer, B., Datson, N.A., Abbott, D.H. , Flibanserin and 8-OH-DPAT Implicate Serotonin in Association between Female Marmoset Monkey Sexual Behavior and Changes in Pair-Bond Quality, J Sex Med, vol. 9, no. 3, pp. 694–707. DOI
Boelen, A., van Beeren, M., Vos, X., Surovtseva, O., Belegri, E., Saaltink, D.J., Vreugdenhil, E., Kalsbeek, A., Kwakkel, J., Fliers, E. , Leptin administration restores the fasting-induced increase of hepatic type 3 deiodinase expression in mice, Thyroid, vol. 22, no. 2, pp. 192-199. DOI
Datson, N.A., Speksnijder, N., Mayer, J.L., Steenbergen, P.J., Korobko, O., Goeman, J., de Kloet, E.R., Joels, M., Lucassen, P.J. , The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus, Hippocampus, vol. 22, no. 2, pp. 359-371. DOI
Sarabdjitsingh, R.A., Conway-Campbell, B.L., Leggett, J.D., Waite, E.J., Meijer, O.C., de Kloet, E.R., Lightman, S.L. , Stress Responsiveness Varies over the Ultradian Glucocorticoid Cycle in a Brain-Region-Specific Manner (vol 151, pg 5369, 2010), Endocrinology, vol. 153, no. 12, pp. 6159-6159. DOI
Claessens, S.E., Daskalakis, N.P., Oitzl, M.S., de Kloet, E.R. , Early handling modulates outcome of neonatal dexamethasone exposure, Horm Behav, vol. 62, no. 4, pp. 433–441. DOI
Schwabe, L., Joels, M., Roozendaal, B., Wolf, O.T., Oitzl, M.S. , Stress effects on memory: An update and integration, Neurosci Biobehav Rev, vol. 36, no. 7, pp. 1740-1749. DOI
Verissimo, C.S., Cheng, S., Puigvert, J.C., Qin, Y., Vroon, A., van Deutekom, J., Price, L.S., Danen, E.H., van de Water, B., Fitzsimons, C.P., Vreugdenhil, E. , Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells, J Pharmacol Exp Ther, vol. 342, no. 1, pp. 119-130. DOI
Ter Horst, J.P., van der Mark, M.H., Arp, M., Berger, S., de Kloet, E.R., Oitzl, M.S. , Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation, Neurobiol Learn Mem, vol. 98, no. 1, pp. 33–40. DOI
Sarabdjitsingh, R.A., Joels, M., de Kloet, E.R. , Glucocorticoid pulsatility and rapid corticosteroid actions in the central stress response, Physiol Behav, vol. 106, no. 1, pp. 73-80. DOI
Claessens, S.E. , Programming the brain: Towards intervention strategies, LACDR, Medical Pharmacology, vol. PhD, Leiden, Leiden University.
Dalm, S. , Towards a mouse model of depression : a psychoneuroendocrine approach, LACDR, Medical Pharmacology, vol. PhD, Leiden, Leiden University, pp. 248.
Aubert, Y. , Sex, Aggression and Pair-Bond: A study on the serotonergic regulation of female sexual function in the Marmoset Monkey, LACDR, Medical Pharmacology, vol. PhD, Leiden, Leiden University, pp. 191.
Verissimo, C.S.L. , Doublecortin-like kinase: a potential therapeutic target for neuroblastoma, LACDR, Medical Pharmacology, vol. PhD, Leiden, Leiden University.
Joels, M., de Kloet, E.R., Karst, H. , Corticosteroid Actions on Neurotransmission, Handbook of Neuroendocrinology, San Diego, Academic Press, pp. 415-431. DOI
Diamantopoulou, A., Raftogianni, A., Stamatakis, A., Alikaridis, F., Oitzl, M.S., Stylianopoulou, F. , Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat, PLoS One, vol. 7, no. 3, pp. e33793. DOI
Deuter, C.E., Kuehl, L.K., Blumenthal, T.D., Schulz, A., Oitzl, M.S., Schachinger, H. , Effects of cold pressor stress on the human startle response, PLoS One, vol. 7, no. 11, pp. e49866. DOI
Steenbergen, P.J., Metz, J.R., Flik, G., Richardson, M.K., Champagne, D.L. , Methods to Quantify Basal and Stress-Induced Cortisol Response in Larval Zebrafish, Zebrafish Neurobehavioral Protocols, vol. 66: Humana Press, Springer, pp. 121-141. DOI
Dalm, S., de Kloet, E.R., Oitzl, M.S. , Post-training reward partially restores chronic stress induced effects in mice, PLoS One, vol. 7, no. 6, pp. e39033. DOI
de Kloet, E.R. , Stress and the Hippocampus, The Clinical Neurobiology of the Hippocampus: An integrative view , Oxford, Oxford University Press. DOI
Sarabdjitsingh, R.A., Kofink, D., Karst, H., de Kloet, E.R., Joels, M. , Stress-induced enhancement of mouse amygdalar synaptic plasticity depends on glucocorticoid and ss-adrenergic activity, PLoS One, vol. 7, no. 8, pp. e42143. DOI
Steenbergen, P.J., Richardson, M.K., Champagne, D.L. , The light-dark preference test for larval zebrafish, Zebrafish Protocols for Neurobehavioral Research, vol. 66: Humana Press, Springer, pp. 21-35. DOI