Project Fitzsimons

Carlos Fitzsimons

My Scientific interest is in understanding the role of microRNAs and
glucocorticoid hormones in the generation of new neurons in the
hippocampus. In doing so, I focus in utilizing RNA interference as a
tool to study and treating neurologic diseases, such as epilepsy,
depression and others, that may be related to chronic alterations in
hippocampal neurogenesis. We use a wide range of RNAi effectors from
synthetic siRNAs to short hairpin RNAs and artificial microRNAs.
A second part of my research focuses on understanding the crosstalk
between G protein coupled receptors (GPCRs) and nuclear receptors for
glucocorticoid hormones in neural cells.
In combination with a Lentivirus vector system, optimized to deliver
RNAi effectors to neurogenic cells in the hippocampus in vivo, our
experimental approach provides and excellent opportunity to contribute
substantially to a currently booming scientific field.